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Please answer the questions to the point and refer to any supporting materials ( try peer reviewed articles) which may be necessary. Use supporting references. 1. Scientific research could be conducted by various methods including laboratory-based methods, animal models, computational studies, clinical trials etc. Define the steps required to design a preclinical drug study in an animal model to test the efficacy of a novel anti-cancer drug. Support your answer with any investigational drug tested in cancer.
2. High calorie content and trans-fat content of fast food are some of the factors contributing to the obesity epidemic in the last 30 years in the United States. Mississippi has a higher level of obesity and both cardiovascular diseases reported. How increasing chronic conditions could be related with health disparity? 3. Obesity could be measured using BMI. Please define BMI and how it is calculated to measure obesity. What are the association between obesity and cardiovascular diseases?